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Meningioma: not always a benign tumor. A review of advances in the treatment of meningiomas.

ABSTRACT: Meningiomas are the most common primary intracranial tumors. The majority of meningiomas are benign, but they can present different grades of dedifferentiation from grade I to grade III (anaplastic/malignant) that are associated with different outcomes. Radiological surveillance is a valid option for low-grade asymptomatic meningiomas. In other cases, the treatment is usually surgical, aimed at achieving a complete resection. The use of adjuvant radiotherapy is the gold standard for grade III, is debated for grade II and is not generally indicated for radically resected grade I meningiomas. The use of systemic treatments is not standardized. Here we report a review of the literature on the clinical, radiological and molecular characteristics of meningiomas, available treatment strategies and ongoing clinical trials.

SUBMITTER: Maggio I

PROVIDER: S-EPMC8162186 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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Meningioma: not always a benign tumor. A review of advances in the treatment of meningiomas.

Maggio Ilaria I Franceschi Enrico E Tosoni Alicia A Nunno Vincenzo Di VD Gatto Lidia L Lodi Raffaele R Brandes Alba A AA

CNS oncology 20210521 2

Meningiomas are the most common primary intracranial tumors. The majority of meningiomas are benign, but they can present different grades of dedifferentiation from grade I to grade III (anaplastic/malignant) that are associated with different outcomes. Radiological surveillance is a valid option for low-grade asymptomatic meningiomas. In other cases, the treatment is usually surgical, aimed at achieving a complete resection. The use of adjuvant radiotherapy is the gold standard for grade III, i ...[more]

PMID: 34015955

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Gene expression analysis during progression of malignant meningioma compared to benign meningioma.

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