Effect of Vitamin D and/or Marine n-3 Fatty Acid Supplementation on Changes in Migraine Frequency and Severity.

ABSTRACT:

Background

There is interest in whether supplements, including vitamin D and marine omega-3 (n-3) fatty acids, may be effective migraine prophylaxis. However, few studies have evaluated whether vitamin D or n-3 fatty acid supplementation may reduce migraine frequency or severity.

Methods

Participants in the VITamin D and OmegA-3 TriaL (VITAL) were assigned to vitamin D₃ (2000 IU/d) or marine n-3 fatty acid (1 g/d) supplementation in a 2-by-2 factorial design. Lifetime history of migraine was assessed a median of 4.6 years after the start of the trial. Individuals were asked to self-report changes in migraine frequency (no change, more frequent, or less frequent) and severity (no change, more severe, less severe) in the past 5 years. We used χ² tests to

SUBMITTER: Rist PM 

PROVIDER: S-EPMC8164960 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature