Hemostatic alterations linked to body fat distribution, fatty liver, and insulin resistance.

ABSTRACT:

Objective

Obesity, in particular visceral obesity, and insulin resistance emerged as major risk factors for severe coronavirus disease 2019 (COVID-19), which is strongly associated with hemostatic alterations. Because obesity and insulin resistance predispose to thrombotic diseases, we investigated the relationship between hemostatic alterations and body fat distribution in participants at risk for type 2 diabetes.

Subjects

Body fat distribution (visceral and subcutaneous abdominal adipose tissue) and liver fat content of 150 participants - with impaired glucose tolerance and/or impaired fasting glucose - were determined using magnetic resonance imaging and spectroscopy. Participants underwent precise metabolic characterization and major hemostasis parameters were analyzed.<

SUBMITTER: Horber S 

PROVIDER: S-EPMC8165974 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature