Genetic variant in microRNA-146a gene is associated with risk of rheumatoid arthritis.

ABSTRACT:

Objective

To investigated the association between single nucleotide polymorphisms (SNPs) in microRNA-146a (miR-146a) gene and susceptibility of rheumatoid arthritis (RA).

Methods

We systemically extracted the genetic data of miR-146a from previous genome-wide association studies (GWASs) of RA. Subsequently, we performed a replication study in an independent Chinese cohort for selected variant. A meta-analysis combined the previous GWASs with the replication study was also conducted. The epigenetic annotation and cytokine assay were used for exploring potential variant function.

Results

The extracted genetic association data from three previous GWASs showed that the allele T of functional SNP rs2431697 increased RA susceptibility. The significant a

SUBMITTER: Zhang LL 

PROVIDER: S-EPMC8172213 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature