Transcription factor enrichment analysis (TFEA) quantifies the activity of multiple transcription factors from a single experiment.

ABSTRACT: Detecting changes in the activity of a transcription factor (TF) in response to a perturbation provides insights into the underlying cellular process. Transcription Factor Enrichment Analysis (TFEA) is a robust and reliable computational method that detects positional motif enrichment associated with changes in transcription observed in response to a perturbation. TFEA detects positional motif enrichment within a list of ranked regions of interest (ROIs), typically sites of RNA polymerase initiation inferred from regulatory data such as nascent transcription. Therefore, we also introduce muMerge, a statistically principled method of generating a consensus list of ROIs from multiple replicates and conditions. TFEA is broadly applicable to data that informs on transcriptional regulation incl

SUBMITTER: Rubin JD 

PROVIDER: S-EPMC8172830 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature