The effect of glutathione as adjuvant therapy on levels of TNF-α and IL-10 in wistar rat peritonitis model.

ABSTRACT:

Background

Peritonitis is the second most common cause of severe sepsis that associated with a significant mortality rate. Due to a large gap of newer antibiotics innovation and antibiotic resistance emergence, the use of antioxidant has a possible alternative as adjuvant therapy in peritonitis management. It has been studied that glutathione as an alternative in the development of new anti-inflammatory effect. Thus, the aim of this study was to evaluate the levels of TNF-α and IL-10 after glutathione administration as adjuvant therapy in rat peritonitis model.

Materials and methods

Male wistar rats were divided into four groups (n = 6 per group), Group 1: control group (C), Group 2: peritonitis group (P), Group 3: peritonitis + Ceftriaxone group (P + Cef), Group 4: peritoni

SUBMITTER: Junita D 

PROVIDER: S-EPMC8178079 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature