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Causal role of cross-frequency coupling in distinct components of cognitive control.

ABSTRACT: Cognitive control is the capacity to guide motor and perceptual systems towards abstract goals. High-frequency neural oscillations related to motor activity in the beta band (13-30 Hz) and to visual processing in the gamma band (>30 Hz) are known to be modulated by cognitive control signals. One proposed mechanism for cognitive control is via cross-frequency coupling whereby low frequency network oscillations in prefrontal cortex (delta from 2-3 Hz and theta from 4-8 Hz) guide the expression of motor-related activity in action planning and guide perception-related activity in memory access. However, there is no causal evidence for cross-frequency coupling in these dissociable components of cognitive control. To address this important gap in knowledge, we delivered cross-frequency transcranial alternating current stimulation (CF-tACS) during performance of a task that manipulated cognitive control demands along two dimensions: the abstraction of the rules of the task (nested levels of action selection) that increased delta-beta coupling and the number of rules (set-size held in memory) that increased theta-gamma coupling. As hypothesized, we found that CF-tACS increased the targeted phase-amplitude coupling and modulated task performance of the associated cognitive control component. These findings provide causal evidence that prefrontal cortex orchestrates different components of cognitive control via two different cross-frequency coupling modalities.

SUBMITTER: Riddle J

PROVIDER: S-EPMC8184612 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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Causal role of cross-frequency coupling in distinct components of cognitive control.

Riddle Justin J McFerren Amber A Frohlich Flavio F

Progress in neurobiology 20210316

Cognitive control is the capacity to guide motor and perceptual systems towards abstract goals. High-frequency neural oscillations related to motor activity in the beta band (13-30 Hz) and to visual processing in the gamma band (>30 Hz) are known to be modulated by cognitive control signals. One proposed mechanism for cognitive control is via cross-frequency coupling whereby low frequency network oscillations in prefrontal cortex (delta from 2-3 Hz and theta from 4-8 Hz) guide the expression of ...[more]

PMID: 33741402

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Project description:Attentional cognitive control regulates the perception to enhance human behaviour. The current study examines the atltentional mechanisms in terms of time and frequency of EEG signals. The cognitive load is higher for processing local attentional stimulus, thereby demanding higher response time (RT) with low response accuracy (RA). On the other hand, the global attentional mechanisms broadly promote the perception while demanding a low cognitive load with faster RT and high RA. Attentional mechanisms refer to perceptual systems that afford and allocate the adaptive behaviours for prioritizing the processing of relevant stimuli based on the local and global features. The early sensory component of C1, which was associated with the local attentional mechanism, showed higher amplitudes than the global attentional mechanisms in parieto-occipital regions. Further, the local attentional mechanisms were also sustained in N2 and P3 components increasing higher amplitude in the left and right hemispheric sides of temporal regions (T7 and T8). Theta band frequency had shown higher power spectrum density (PSD) values while processing local attentional mechanisms. However, the significance of other frequency bands was noticeably minute. Hence, integrating the attentional mechanisms in terms of ERP and frequency signatures, a hybrid custom weight allocation model (CWAM) was built to assess and predict the contribution of insignificant channels to significant ones. The CWAM model was formulated based on the computational linear regression derivatives. All the derivatives are computationally derived the significant score while channelizing the hierarchical performance of each channel with respect to the frequent and deviant occurrences of global-local stimulus. This model enables us to configure the neural dynamicity of cognitive allocation of resources within the different locations of the human brain while processing the attentional stimulus. CWAM is reported to be the first model to evaluate the performance of the non-significant channels for enhancing the response of significant channels. The findings of the CWAM model suggest that the brain's performance may be determined by the underlying contribution of the non-significant channels.Supplementary informationThe online version contains supplementary material available at 10.1007/s11571-022-09888-x.

Project description:Neuroimaging studies have identified networks of brain areas and oscillations associated with tinnitus perception. However, how these regions relate to perceptual characteristics of tinnitus, and how oscillations in various frequency bands are associated with communications within the tinnitus network is still incompletely understood. Recent evidence suggests that apart from changes of the tinnitus severity the changes of tinnitus dominant pitch also have modulating effect on the underlying neuronal activity in a number of brain areas within the tinnitus network. Therefore, in a re-analysis of an existing dataset, we sought to determine how the oscillations in the tinnitus network in the various frequency bands interact. We also investigate how changes of tinnitus loudness, annoyance and pitch affect cross-frequency interaction both within and between nodes of the tinnitus network. Results of this study provide, to our knowledge, the first evidence that in tinnitus patients, aside from the previously described changes of oscillatory activity, there are also changes of cross-frequency coupling (CFC); phase-amplitude CFC was increased in tinnitus patients within the auditory cortex and the dorsolateral prefrontal regions between the phase of delta-theta and the amplitude of gamma oscillations (Modulation Index [MI] 0.17 in tinnitus patients vs. 0.08 in tinnitus free controls). Moreover, theta phase in the anterior cingulate region modulated gamma in the auditory (MI 0.1) and dorsolateral prefrontal regions (MI 0.19). Reduction of tinnitus severity after acoustic coordinated reset therapy led to a partial normalization of abnormal CFC. Also treatment induced changes in tinnitus pitch significantly modulated changes in CFC. Thus, tinnitus perception is associated with a more pronounced CFC within and between nodes of the tinnitus network. CFC can coordinate tinnitus-relevant activity in the tinnitus network providing a mechanism for effective communication between nodes of this network.

Project description:IntroductionElectroencephalographic (EEG) abnormalities are seen in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) with characteristic features of cognitive impairment. The most common findings of EEG features in AD and MCI patients are increased relative power of slow oscillations (delta and theta rhythms) and decreased relative power of fast oscillations (alpha, beta and gamma rhythms). However, impairments in cognitive processes in AD and MCI are not sufficiently reflected by brain oscillatory activity in a particular frequency band. MCI patients are at high risk of progressing to AD. Cross-frequency coupling (CFC), which refers to coupling between different frequency bands, is a crucial tool for comprehending changes in brain oscillations and cognitive performance. CFC features exhibit some specificity in patients with AD and MCI, but a comparison between CFC features in individuals with these disorders is still lacking. The aim of this study was to explore changes in CFC properties in MCI and AD and to explore the relationship between CFC properties and multiple types of cognitive functional performance.MethodsWe recorded resting-state EEG (rsEEG) signals in 46 MCI patients, 43 AD patients, and 43 cognitively healthy controls (HCs) and analyzed the changes in CFC as well as the relationship between CFC and scores on clinical tests of cognitive function.Results and discussionMultiple couplings between low-frequency oscillations and high-frequency oscillations were found to be significantly enhanced in AD patients compared to those of HCs and MCI, while delta-gamma as well as theta-gamma couplings in the right temporal and parietal lobes were significantly enhanced in MCI patients compared to HCs. Moreover, theta-gamma coupling in the right temporal lobe tended to be stronger in MCI patients than in HCs, and it was stronger in AD than in MCI. Multiple CFC properties were found to correlate significantly with various cognitive domains, especially the memory function domain. Overall, these findings suggest that AD and MCI patients must use more neural resources to maintain a resting brain state and that alterations in theta-gamma coupling in the temporal lobe become progressively obvious during disease progression and are likely to be a valuable indicator of MCI and AD pathology.

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Causal role of cross-frequency coupling in distinct components of cognitive control.

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Causal role of cross-frequency coupling in distinct components of cognitive control.

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