Asymptomatic COVID-19: disease tolerance with efficient anti-viral immunity against SARS-CoV-2.

ABSTRACT: The immune responses and mechanisms limiting symptom progression in asymptomatic cases of SARS-CoV-2 infection remain unclear. We comprehensively characterized transcriptomic profiles, cytokine responses, neutralization capacity of antibodies, and cellular immune phenotypes of asymptomatic patients with acute SARS-CoV-2 infection to identify potential protective mechanisms. Compared to symptomatic patients, asymptomatic patients had higher counts of mature neutrophils and lower proportion of CD169⁺ expressing monocytes in the peripheral blood. Systemic levels of pro-inflammatory cytokines were also lower in asymptomatic patients, accompanied by milder pro-inflammatory gene signatures. Mechanistically, a more robust systemic Th2 cell signature with a higher level of virus-specifi

SUBMITTER: Chan YH 

PROVIDER: S-EPMC8185544 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature