Distinct properties of Ca²⁺ efflux from brain, heart and liver mitochondria: The effects of Na⁺, Li⁺ and the mitochondrial Na⁺/Ca²⁺ exchange inhibitor CGP37157.

ABSTRACT: Mitochondrial Ca²⁺ transport is essential for regulating cell bioenergetics, Ca²⁺ signaling and cell death. Mitochondria accumulate Ca²⁺ via the mitochondrial Ca²⁺ uniporter (MCU), whereas Ca²⁺ is extruded by the mitochondrial Na⁺/Ca²⁺ (mtNCX) and H⁺/Ca²⁺ exchangers. The balance between these processes is essential for preventing toxic mitochondrial Ca²⁺ overload. Recent work demonstrated that MCU activity varies significantly among tissues, likely reflecting tissue-specific Ca²⁺ signaling and energy needs. It is less clear whether this diversity in MCU activity is matched by tissue-specific diversity in mitochondrial Ca²⁺ extrusion. Here we compared propertie

SUBMITTER: Rysted JE 

PROVIDER: S-EPMC8187304 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature