Induced pluripotent stem cells provide mega insights into kidney disease.

ABSTRACT: Rare mutations in the LRP2 gene encoding for the endocytic receptor megalin cause developmental abnormalities and kidney disease. However, the mechanisms governing the dysfunction of mutant megalin remain unclear. A new study utilizing patient-derived induced pluripotent stem cells is now putting the endolysosomal system into the spotlight, as it is proposed to play a central role in the regulation of megalin in health and disease.

SUBMITTER: Luciani A 

PROVIDER: S-EPMC8204406 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature