Unknown

Dataset Information

0

Three New Quinazoline-Containing Indole Alkaloids From the Marine-Derived Fungus Aspergillus sp. HNMF114.

ABSTRACT: By feeding tryptophan to the marine-derived fungus Aspergillus sp. HNMF114 from the bivalve mollusk Sanguinolaria chinensis, 3 new quinazoline-containing indole alkaloids, named aspertoryadins H-J (1-3), along with 16 known ones (4-19), were obtained. The structures of the new compounds were elucidated by the analysis of spectroscopic data combined with quantum chemical calculations of nuclear magnetic resonance (NMR) chemical shifts and electron capture detector (ECD) spectra. Structurally, compound 3 represents the first example of this type of compound, bearing an amide group at C-3. Compounds 10 and 16 showed potent α-glucosidase inhibitory activity with IC50 values of 7.18 and 5.29 μM, and compounds 13 and 14 showed a clear activation effect on the ryanodine receptor from Spodoptera frugiperda (sfRyR), which reduced the [Ca2+] ER by 37.1 and 36.2%, respectively.

SUBMITTER: Liu SS 

PROVIDER: S-EPMC8206283 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Three New Quinazoline-Containing Indole Alkaloids From the Marine-Derived Fungus <i>Aspergillus</i> sp. HNMF114.

Liu Sha-Sha SS   Yang Li L   Kong Fan-Dong FD   Zhao Jia-Hui JH   Yao Li L   Yuchi Zhi-Guang ZG   Ma Qing-Yun QY   Xie Qing-Yi QY   Zhou Li-Man LM   Guo Meng-Fei MF   Dai Hao-Fu HF   Zhao You-Xing YX   Luo Du-Qiang DQ  

Frontiers in microbiology 20210602

By feeding tryptophan to the marine-derived fungus <i>Aspergillus</i> sp. HNMF114 from the bivalve mollusk <i>Sanguinolaria chinensis</i>, 3 new quinazoline-containing indole alkaloids, named aspertoryadins H-J (<b>1</b>-<b>3</b>), along with 16 known ones (<b>4</b>-<b>19</b>), were obtained. The structures of the new compounds were elucidated by the analysis of spectroscopic data combined with quantum chemical calculations of nuclear magnetic resonance (NMR) chemical shifts and electron capture  ...[more]

Similar Datasets

Unknown Bioactive Indole Diketopiperazine Alkaloids from the Marine Endophytic Fungus Aspergillus sp. YJ191021.
| S-EPMC8002477 | biostudies-literature
Unknown Indole Diketopiperazine Alkaloids Isolated From the Marine-Derived Fungus <i>Aspergillus chevalieri</i> MCCC M23426.
| S-EPMC9301495 | biostudies-literature
Unknown Isolation of notoamide E, a key precursor in the biosynthesis of prenylated indole alkaloids in a marine-derived fungus, Aspergillus sp.
| S-EPMC2671082 | biostudies-literature
Unknown Cytotoxic indole alkaloids and polyketides produced by a marine-derived fungus <i>Aspergillus flavipes</i> DS720.
| S-EPMC9355579 | biostudies-literature
Unknown New Prenylated Indole Homodimeric and Pteridine Alkaloids from the Marine-Derived Fungus Aspergillus austroafricanus Y32-2.
| S-EPMC7916005 | biostudies-literature
Unknown Indole Diketopiperazine Alkaloids from the Marine Sediment-Derived Fungus <i>Aspergillus chevalieri</i> against Pancreatic Ductal Adenocarcinoma.
| S-EPMC10820104 | biostudies-literature
Unknown Identification of Filovirus Entry Inhibitors from Marine Fungus-Derived Indole Alkaloids.
| S-EPMC11766795 | biostudies-literature
Unknown Sclerotioloids A-C: Three New Alkaloids from the Marine-Derived Fungus <i>Aspergillus sclerotiorum</i> ST0501.
| S-EPMC10142895 | biostudies-literature
Unknown Methylthio-aspochalasins from a marine-derived fungus Aspergillus sp.
| S-EPMC4210888 | biostudies-literature
Unknown Antibacterial Secondary Metabolites from Marine-Derived Fungus Aspergillus sp. IMCASMF180035.
| S-EPMC8066187 | biostudies-literature