Cytotoxic indole alkaloids and polyketides produced by a marine-derived fungus Aspergillus flavipes DS720.

ABSTRACT: Marine-derived microorganisms possess the unique metabolic pathways to produce structurally novel secondary metabolites with potent biological activities. In this study, bioactivity-guided isolation of the marine deep-sea-derived fungus Aspergillus flavipes DS720 led to the characterization of four indole alkaloids (compounds 1-4) and four polyketides (compounds 5-8), such as two new indoles, flavonoids A (1) and B (2) with a C-6 reversed prenylation, and a new azaphilone, flaviazaphilone A (5). Their chemical structures were unambiguously established by an extensive interpretation of spectroscopic data, such as 1D/2D NMR and HRESIMS data. The absolute configurations of the new compound 5 were solved by comparing the experiment

SUBMITTER: Xu A 

PROVIDER: S-EPMC9355579 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature