Early Stage Longitudinal Subcortical Volumetric Changes following Mild Traumatic Brain Injury.

ABSTRACT: Objective: To investigate early brain volumetric changes from acute to 6 months following mild traumatic brain injury (mTBI) in deep gray matter regions and their association with patient 6-month outcome.Methods: Fifty-six patients with mTBI underwent MRI and behavioral evaluation at acute (<10 days) and approximately 1 and 6 months post injury. Regional volume changes were investigated in key gray matter regions: thalamus, hippocampus, putamen, caudate, pallidum, and amygdala, and compared with volumes from 34 healthy control subjects. In patients with mTBI, we further assessed associations between longitudinal regional volume changes with patient outcome measures at 6 months including post-concussive symptoms, cognitive performance, and overall satisfaction with life.Res

SUBMITTER: Zhuo J 

PROVIDER: S-EPMC8207827 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature