Age-related telomere attrition causes aberrant gene expression in sub-telomeric regions.
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ABSTRACT:
SUBMITTER: Dong X
PROVIDER: S-EPMC8208793 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Publications
Age-related telomere attrition causes aberrant gene expression in sub-telomeric regions.
Dong Xiao X Sun Shixiang S Zhang Lei L Kim Seungsoo S Tu Zhidong Z Montagna Cristina C Maslov Alexander Y AY Suh Yousin Y Wang Tao T Campisi Judith J Vijg Jan J
Aging cell 20210521 6
Telomere attrition has been proposed as a biomarker and causal factor in aging. In addition to causing cellular senescence and apoptosis, telomere shortening has been found to affect gene expression in subtelomeric regions. Here, we analyzed the distribution of age-related differentially expressed genes from the GTEx RNA sequencing database of 54 tissue types from 979 human subjects and found significantly more upregulated than downregulated genes in subtelomeric regions as compared to the genom ...[more]
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