Trajectory of Cognitive Decline After Sepsis.

ABSTRACT:

Objectives

Cognitive impairment is an important consequence of sepsis. We sought to determine long-term trajectories of cognitive function after sepsis.

Design

Prospective study of the Reasons for Geographic and Racial Differences in Stroke cohort.

Setting

United States.

Patients

Twenty-one thousand eight-hundred twenty-three participants greater than or equal to 45 years, mean (sd) age 64.3 (9.2) years at first cognitive assessment, 30.9% men, and 27.1% Black.

Measurements and main results

The main exposure was time-dependent sepsis hospitalization. The primary outcome was global cognitive function (Six-Item Screener range, 0-6). Secondary outcomes were incident cognitive impairment (Six-Item Screener score ≤ 4 [impaired] vs ≥5 [unimpaired]), new learni

SUBMITTER: Wang HE 

PROVIDER: S-EPMC8217073 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature