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ABSTRACT: Aims
Although there is increasing evidence supporting coronary atherosclerosis evaluation by coronary computed tomography angiography (CCTA), no data are available on age and sex differences for quantitative plaque features. The aim of this study was to investigate sex and age differences in both qualitative and quantitative atherosclerotic features from CCTA prior to acute coronary syndrome (ACS).Methods and results
Within the ICONIC study, in which 234 patients with subsequent ACS were propensity matched 1:1 with 234 non-event controls, our current subanalysis included only the ACS cases. Both qualitative and quantitative advance plaque analysis by CCTA were performed by a core laboratory. In 129 cases, culprit lesions identified by invasive coronary angiography at the time of ACS were co-registered to baseline CCTA precursor lesions. The study population was then divided into subgroups according to sex and age (<65 vs. ≥ 65 years old) for analysis. Older patients had higher total plaque volume than younger patients. Within specific subtypes of plaque volume, however, only calcified plaque volume was higher in older patients (135.9 ± 163.7 vs. 63.8 ± 94.2 mm3, P < 0.0001, respectively). Although no sex-related differences were recorded for calcified plaque volume, females had lower fibrous and fibrofatty plaque volume than males (Fibrofatty volume 29.6 ± 44.1 vs. 75.3 ± 98.6 mm3, P = 0.0001, respectively). No sex-related differences in the prevalence of qualitative high-risk plaque features were found, even after separate analyses considering age were performed.Conclusion
Our data underline the importance of age- and sex-related differences in coronary atherosclerosis presentation, which should be considered during CCTA-based atherosclerosis quantification.
SUBMITTER: Conte E
PROVIDER: S-EPMC8218779 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Conte Edoardo E Dwivedi Aeshita A Mushtaq Saima S Pontone Gianluca G Lin Fay Y FY Hollenberg Emma J EJ Lee Sang-Eun SE Bax Jeroen J Cademartiri Filippo F Chinnaiyan Kavitha K Chow Benjamin J W BJW Cury Ricardo C RC Feuchtner Gudrun G Hadamitzky Martin M Kim Yong-Jin YJ Baggiano Andrea A Leipsic Jonathon J Maffei Erica E Marques Hugo H Plank Fabian F Raff Gilbert L GL van Rosendael Alexander R AR Villines Todd C TC Weirich Harald G HG Al'Aref Subhi J SJ Baskaran Lohendran L Cho Iksung I Danad Ibrahim I Han Donghee D Heo Ran R Lee Ji Hyun JH Stuijfzand Wijnand J WJ Gransar Heidi H Lu Yao Y Sung Ji Min JM Park Hyung-Bok HB Al-Mallah Mouaz H MH de Araújo Gonçalves Pedro P Berman Daniel S DS Budoff Matthew J MJ Samady Habib H Shaw Leslee J LJ Stone Peter H PH Virmani Renu R Narula Jagat J Min James K JK Chang Hyuk-Jae HJ Andreini Daniele D
European heart journal. Cardiovascular Imaging 20210101 1
<h4>Aims</h4>Although there is increasing evidence supporting coronary atherosclerosis evaluation by coronary computed tomography angiography (CCTA), no data are available on age and sex differences for quantitative plaque features. The aim of this study was to investigate sex and age differences in both qualitative and quantitative atherosclerotic features from CCTA prior to acute coronary syndrome (ACS).<h4>Methods and results</h4>Within the ICONIC study, in which 234 patients with subsequent ...[more]