Predicting response to cognitive training for schizophrenia using results from two studies with different outcomes.

ABSTRACT:

Background

Collaborative data sharing between research groups provides an opportunity to explore the basis for the heterogeneity in cognitive training outcomes reported in the schizophrenia literature. The current analyses focused on the contribution of site and participant characteristics to these heterogeneous outcomes.

Methods

Data from two independent studies, from New York (NY) and Los Angeles (LA), were combined to yield a sample of 132 outpatient adults with schizophrenia/schizoaffective disorder. While similar treatment doses, cognitive exercises and outcome measures were used, sites differed in use of coaching, group discussion and compensation. Between-site differences in participant demographic and baseline clinical characteristics were tested. Regression examined

SUBMITTER: Saperstein AM 

PROVIDER: S-EPMC8222143 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature