A Pilot Study of Associations Between Visceral Fat, IL-6, and Urinary F₂-Isoprostanes in Older Adults Exposed to a Diet Intervention.

ABSTRACT:

Background

Short-term markers of successful visceral adipose tissue (VAT) loss are needed. Urinary F₂-isoprostanes might serve as a marker for intensified lipid metabolism, whereas circulating IL-6 might stimulate fat oxidation and enhance mobilization of VAT.

Objectives

This pilot study was designed to explore the hypotheses that 1) reduction in VAT is associated with increase in IL-6, and 2) that increases in urinary F₂-isoprostanes are associated with increases in IL-6 and reduction in VAT.

Methods

Eighteen participants (aged 60-75 y, BMI 30-40 kg/m²) were randomly assigned to either a very-low-carbohydrate diet (VLCD; <10:25:>65% energy from carbohydrate:protein:fat) or a low-fat diet (LFD; 55:25:20%) for 8 wk. Change

SUBMITTER: Hoover SE 

PROVIDER: S-EPMC8238660 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature