The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives.

ABSTRACT: Pancreatic cancer is an increasingly common cause of cancer mortality with a tight correspondence between disease mortality and incidence. Furthermore, it is usually diagnosed at an advanced stage with a very dismal prognosis. Due to the high heterogeneity, metabolic reprogramming, and dense stromal environment associated with pancreatic cancer, patients benefit little from current conventional therapy. Recent insight into the biology and genetics of pancreatic cancer has supported its molecular classification, thus expanding clinical therapeutic options. In this review, we summarize how the biological features of pancreatic cancer and its metabolic reprogramming as well as the tumor microenvironment regulate its development and progression. We further discuss potential biomarkers for panc

SUBMITTER: Wang S 

PROVIDER: S-EPMC8255319 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature