Ferroptosis-related gene signature predicts prognosis and immunotherapy in glioma.

ABSTRACT:

Aims

Glioma is a highly invasive brain tumor, which makes prognosis challenging and renders patients resistant to various treatments. Induction of cell death is promising in cancer therapy. Ferroptosis, a recently discovered regulated cell death, can be induced for killing glioma cells. However, the prognostic prediction of ferroptosis-related genes (FRGs) in glioma remains elusive.

Methods

The mRNA expression profiles and gene variation and corresponding clinical data of glioma patients and NON-TUMOR control were downloaded from public databases. Risk score based on a FRGs signature was constructed in REMBRANDT cohort and validated in other datasets including CGGA-693, CGGA-325, and TCGA.

Results

Our results demonstrated that the majority of FRGs was differentially e

SUBMITTER: Wan RJ 

PROVIDER: S-EPMC8265949 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature