Small airway dilation measured by endoscopic optical coherence tomography correlates with chronic lung allograft dysfunction.

ABSTRACT: Chronic lung allograft dysfunction (CLAD) is the leading cause of death in transplant patients who survive past the first year post-transplant. Current diagnosis is based on sustained decline in lung function; there is a need for tools that can identify CLAD onset. Endoscopic optical coherence tomography (OCT) can visualize structural changes in the small airways, which are of interest in CLAD progression. We aim to identify OCT features in the small airways of lung allografts that correlate with CLAD status. Imaging was conducted with an endoscopic rotary pullback OCT catheter during routine bronchoscopy procedures (n  =  54), collecting volumetric scans of three segmental airways per patient. Six features of interest were identified, and four blinded raters scored the dataset on the pres

SUBMITTER: Malone J 

PROVIDER: S-EPMC8278781 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature