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Catalyst-free arylation of sulfonamides via visible light-mediated deamination.

ABSTRACT: A novel arylation of sulfonamides with boronic acids to afford numerous diaryl sulfones via a visible light-mediated N-S bond cleavage other than the typical transition-metal-catalyzed C(O)-N bond activation is described. This methodology, which represents the first catalyst-free protocol for the sulfonylation of boronic acids, is characterized by its simple reaction conditions, good functional group tolerance and high efficiency. Several successful examples for the late-stage functionalization of diverse sulfonamides indicate the high potential utility of this method in pharmaceutical science and organic synthesis.

SUBMITTER: Luo Y

PROVIDER: S-EPMC8279011 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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Catalyst-free arylation of sulfonamides via visible light-mediated deamination.

Luo Yong Y Ding Hao H Zhen Jing-Song JS Du Xian X Xu Xiao-Hong XH Yuan Han H Li Yi-Hui YH Qi Wan-Ying WY Liu Bing-Zhe BZ Lu Shi-Man SM Xue Can C Ding Qiuping Q

Chemical science 20210605 27

A novel arylation of sulfonamides with boronic acids to afford numerous diaryl sulfones via a visible light-mediated N-S bond cleavage other than the typical transition-metal-catalyzed C(O)-N bond activation is described. This methodology, which represents the first catalyst-free protocol for the sulfonylation of boronic acids, is characterized by its simple reaction conditions, good functional group tolerance and high efficiency. Several successful examples for the late-stage functionali ...[more]

PMID: 34349930

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Author Correction: Visible-light-driven Photocatalytic N-arylation of Imidazole Derivatives and Arylboronic Acids on Cu/graphene catalyst.

Project description: Not available

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