Dataset Information

The effectiveness of rotating versus single course antibiotics for small intestinal bacterial overgrowth.

ABSTRACT:

Background

Small intestinal bacterial overgrowth treatment is usually based on antibiotics with no guidelines available.

Objective

This study aimed to investigate the efficacy of different antibiotics to treat small intestinal bacterial overgrowth.

Methods

Consecutive patients referred to our tertiary center and diagnosed with intestinal bacterial overgrowth were retrospectively included. Patients were diagnosed using a 75 g glucose breath test. Patients were treated either with a single antibiotic (quinolone or azole) or rotating antibiotics (quinolone and azole, one after the other) for 10 consecutive days per month for 3 months. A negative glucose breath test after antibiotic treatment was considered as remission. Quality of life (GIQLI) and gastrointestinal severity (IBS-SSS) were assessed before and after antibiotic treatment. Symptomatic evaluation was realized in simple blind of glucose breath test result: patients were unaware of their results.

Results

Between August 2005 and February 2020, 223 patients were included in the analysis (female 79.8%, mean age 50.2 ± 15.7 years). Remission was observed in 119 patients (53.4%) after one course of antibiotics and was more frequent in patients receiving rotating antibiotics than in patients receiving a single antibiotic (70.0% vs. 50.8%, p = 0.050). Remission was associated with a significant improvement in quality of life (p = 0.035) and in bloating (p = 0.004).

Conclusion

In this study, the treatment of small intestinal bacterial overgrowth using rotating antibiotics was more effective than treatment using a single course of antibiotic. Remission was associated with improvement in both quality of life and bloating.

SUBMITTER: Richard N

PROVIDER: S-EPMC8280793 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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Publications

The effectiveness of rotating versus single course antibiotics for small intestinal bacterial overgrowth.

Richard Nicolas N Desprez Charlotte C Wuestenberghs Fabien F Leroi Anne-Marie AM Gourcerol Guillaume G Melchior Chloé C

United European gastroenterology journal 20210709 6

<h4>Background</h4>Small intestinal bacterial overgrowth treatment is usually based on antibiotics with no guidelines available.<h4>Objective</h4>This study aimed to investigate the efficacy of different antibiotics to treat small intestinal bacterial overgrowth.<h4>Methods</h4>Consecutive patients referred to our tertiary center and diagnosed with intestinal bacterial overgrowth were retrospectively included. Patients were diagnosed using a 75 g glucose breath test. Patients were treated either ...[more]

PMID: 34241973

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Dataset Information

The effectiveness of rotating versus single course antibiotics for small intestinal bacterial overgrowth.

Background

Objective

Methods

Results

Conclusion

Publications

The effectiveness of rotating versus single course antibiotics for small intestinal bacterial overgrowth.

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