Reinforcer pathology in cocaine use disorder: Temporal window determines cocaine valuation.

ABSTRACT:

Aims

The Experimental Medicine Approach offers a unique perspective to determine clinical behavior change by engaging a target underlying the cause of a disorder. The present work engaged a novel target of addiction, Reinforcer Pathology, in two studies to test changes in behavior among individuals with cocaine use disorder.

Methods

In Study 1, n = 44 participants engaged the temporal window with episodic future thinking (EFT), a positive prospection exercise. Changes in temporal view and cocaine valuation were tested using delay discounting and behavioral economic demand, respectively. Additionally, a computational model assessed the relative reliance on the near- and far-sighted systems during EFT. In Study 2, n = 71 engaged the temporal window with a negatively-valenced h

SUBMITTER: Snider SE 

PROVIDER: S-EPMC8282732 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature