Dataset Information

Isolation, characterization, anti-MRSA evaluation, and in-silico multi-target anti-microbial validations of actinomycin X₂ and actinomycin D produced by novel Streptomyces smyrnaeus UKAQ_23.

ABSTRACT: Streptomyces smyrnaeus UKAQ_23, isolated from the mangrove-sediment, collected from Jubail,Saudi Arabia, exhibited substantial antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA), including non-MRSA Gram-positive test bacteria. The novel isolate, under laboratory-scale conditions, produced the highest yield (561.3 ± 0.3 mg/kg fermented agar) of antimicrobial compounds in modified ISP-4 agar at pH 6.5, temperature 35 °C, inoculum 5% v/w, agar 1.5% w/v, and an incubation period of 7 days. The two major compounds, K₁ and K₂, were isolated from fermented medium and identified as Actinomycin X₂ and Actinomycin D, respectively, based on their structural analysis. The antimicrobial screening showed that Actinomycin X₂ had t

SUBMITTER: Qureshi KA

PROVIDER: S-EPMC8282855 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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Dataset Information

Isolation, characterization, anti-MRSA evaluation, and in-silico multi-target anti-microbial validations of actinomycin X₂ and actinomycin D produced by novel Streptomyces smyrnaeus UKAQ_23.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Isolation, characterization, anti-MRSA evaluation, and in-silico multi-target anti-microbial validations of actinomycin X2 and actinomycin D produced by novel Streptomyces smyrnaeus UKAQ_23.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Isolation, characterization, anti-MRSA evaluation, and in-silico multi-target anti-microbial validations of actinomycin X₂ and actinomycin D produced by novel Streptomyces smyrnaeus UKAQ_23.