Ratio of FEV₁/Slow Vital Capacity of < 0.7 Is Associated With Clinical, Functional, and Radiologic Features of Obstructive Lung Disease in Smokers With Preserved Lung Function.

ABSTRACT:

Background

Mild expiratory flow limitation may not be recognized using traditional spirometric criteria based on the ratio of FEV₁/FVC.

Research question

Does slow vital capacity (SVC) instead of FVC increase the sensitivity of spirometry to identify patients with early or mild obstructive lung disease?

Study design and methods

We included 854 current and former smokers from the Subpopulations and Intermediate Outcome Measures in COPD Study cohort with a postbronchodilator FEV₁/FVC ≥ 0.7 and FEV₁ % predicted of ≥ 80% at enrollment. We compared baseline characteristics, chest CT scan features, exacerbations, and progression to COPD (postbronchodilator FEV₁/FVC, < 0.7) during the follow-up period between 734 participants with

SUBMITTER: Fortis S 

PROVIDER: S-EPMC8295909 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature