Proteomics reveals disturbances in the immune response and energy metabolism of monocytes from patients with septic shock.

ABSTRACT: Sepsis results from a dyshomeostatic response to infection, which may lead to hyper or hypoimmune states. Monocytes are central regulators of the inflammatory response, but our understanding of their role in the genesis and resolution of sepsis is still limited. Here, we report a comprehensive exploration of monocyte molecular responses in a cohort of patients with septic shock via proteomic profiling. The acute stage of septic shock was associated with an impaired inflammatory phenotype, indicated by the down-regulation of MHC class II molecules and proinflammatory cytokine pathways. Simultaneously, there was an up-regulation of glycolysis enzymes and a decrease in proteins related to the citric acid cycle and oxidative phosphorylation. On the other hand, the restoration of immunocompeten

SUBMITTER: de Azambuja Rodrigues PM 

PROVIDER: S-EPMC8313678 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature