Design, synthesis, characterization, and antioxidant activity studies of novel thienyl-pyrazoles.

ABSTRACT: In a sustained search for novel and effective antioxidants, a potential therapeutic leads against renal, and neurological disorders. Amongst the heterocycles, pyrazole and their derivatives have been extensively studied for their biological potencies, particularly to a larger extent for their antioxidant properties. Although many of pyrazole derivatives displayed antioxidant activities, still there is a need of developing efficient protocol for their synthesis, involving ecofriendly conditions, molecules of greater antioxidant efficacy and lesser toxicity, etc. In this context, the current study presents an amberlyst-15 catalysed efficient synthesis of 2-pyrazoline derivatives, 5(a-g) via (3 + 2) annulation of chalcones with phenylhydrazines. Structure proofs of new py

SUBMITTER: Kumara K 

PROVIDER: S-EPMC8322289 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature