Cardiovascular and Kidney Outcomes Across the Glycemic Spectrum: Insights From the UK Biobank.

ABSTRACT:

Background

Treatment guidelines for prediabetes primarily focus on glycemic control and lifestyle management. Few evidence-based cardiovascular and kidney risk-reduction strategies are available in this population.

Objectives

This study sought to characterize cardiovascular and kidney outcomes across the glycemic spectrum.

Methods

Among participants in the UK Biobank without prevalent type 1 diabetes, cardiovascular disease, or kidney disease, Cox models tested the association of glycemic exposures (type 2 diabetes [T2D], prediabetes, normoglycemia) with outcomes (atherosclerotic cardiovascular disease [ASCVD], chronic kidney disease [CKD], and heart failure), adjusting for demographic, lifestyle, and cardiometabolic risk factors.

Results

Among 336,709 individu

SUBMITTER: Honigberg MC 

PROVIDER: S-EPMC8324525 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature