Hydroxyl radical is a significant player in oxidative DNA damage in vivo.
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ABSTRACT:
SUBMITTER: Halliwell B
PROVIDER: S-EPMC8328964 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
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Hydroxyl radical is a significant player in oxidative DNA damage in vivo.
Halliwell Barry B Adhikary Amitava A Dingfelder Michael M Dizdaroglu Miral M
Chemical Society reviews 20210615 15
Recent publications have suggested that oxidative DNA damage mediated by hydroxyl radical (˙OH) is unimportant in vivo, and that carbonate anion radical (CO<sub>3</sub>˙<sup>-</sup>) plays the key role. We examine these claims and summarize the evidence that ˙OH does play a key role as an important member of the reactive oxygen species (ROS) in vivo. ...[more]
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