RAGE does not contribute to renal injury and damage upon ischemia/reperfusion-induced injury.
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ABSTRACT:
SUBMITTER: Dessing MC
PROVIDER: S-EPMC8336648 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
RAGE does not contribute to renal injury and damage upon ischemia/reperfusion-induced injury.
Dessing Mark C MC Pulskens Wilco P WP Teske Gwendoline J GJ Butter Loes M LM van der Poll Tom T Yang Huan H Tracey Kevin J KJ Nawroth Peter P PP Bierhaus Angelika A Florquin Sandrine S Leemans Jaklien C JC
Journal of innate immunity 20111104 1
The receptor for advanced glycation end products (RAGE) mediates a variety of inflammatory responses in renal diseases, but its role in renal ischemia/reperfusion (I/R) injury is unknown. We showed that during renal I/R, RAGE ligands HMGB1 and S100B are expressed. However, RAGE deficiency does not affect renal injury and function upon I/R-induced injury. ...[more]
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