Resident macrophages restrain pathological adipose tissue remodeling and protect vascular integrity in obese mice.
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ABSTRACT:
SUBMITTER: Chen Q
PROVIDER: S-EPMC8339675 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Publications
Resident macrophages restrain pathological adipose tissue remodeling and protect vascular integrity in obese mice.
Chen Qi Q Lai Si Min SM Xu Shaohai S Tan Yingrou Y Leong Keith K Liu Dehua D Tan Jia Chi JC Naik Roshan Ratnakar RR Barron Anna M AM Adav Sunil S SS Chen Jinmiao J Chong Shu Zhen SZ Ng Lai Guan LG Ruedl Christiane C
EMBO reports 20210701 8
Tissue-resident macrophages in white adipose tissue (WAT) dynamically adapt to the metabolic changes of their microenvironment that are often induced by excess energy intake. Currently, the exact contribution of these macrophages in obesity-driven WAT remodeling remains controversial. Here, using a transgenic CD169-DTR mouse strain, we provide new insights into the interplay between CD169<sup>+</sup> adipose tissue macrophages (ATMs) and their surrounding WAT microenvironment. Using targeted in ...[more]
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