A Systematic Review of Anogenital Distance and Gynecological Disorders: Endometriosis and Polycystic Ovary Syndrome.

ABSTRACT:

Background and aim

Anogenital distance (AGD) can serve as a life-long indicator of androgen action in gestational weeks 8-14. AGD has been used as an important tool to investigate the exposure to endocrine-disrupting compounds in newborns and in individuals with male reproductive disorder. Endometriosis and polycystic ovary syndrome (PCOS) are two common gynecological disorders and both are related to prenatal androgen levels. Therefore, we performed a systematic review to evaluate the relationships of AGD with these gynecological disorders.

Methods

PubMed, Web of Science, and Embase were searched for published studies up to January 25, 2021. No language restriction was implemented.

Results

Ten studies were included in this review. Five focused on women with endometri

SUBMITTER: Pan Z 

PROVIDER: S-EPMC8339921 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature