Dissociation Between Long-term Weight Loss Intervention and Blood Pressure: an 18-month Randomized Controlled Trial.

ABSTRACT:

Background

Obesity is associated with elevated blood pressure (BP). In patients with obesity and hypertension, weight loss lowers BP, but the long-term effect of weight loss on BP is less clear.

Objective

We aimed to assess the effect of long-term weight loss intervention on BP in normotensive and hypertensive subjects.

Design

Randomized controlled trial.

Participants

Two hundred seventy-eight subjects (mean age 47.9 ± 9.3 years, 89% male, 56% hypertensive) with abdominal obesity or elevated serum triglycerides and low high-density lipoprotein cholesterol were recruited.

Intervention

Eighteen-month weight loss intervention.

Main measures

Body weight and BP were measured at baseline, after 6 and 18 months.

Results

After 6 months of intervent

SUBMITTER: Gepner Y 

PROVIDER: S-EPMC8342649 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature