Radiation and adjuvant drug-loaded liposomes target glioblastoma stem cells and trigger in-situ immune response.

ABSTRACT:

Background

The radio- and chemo-resistance of glioblastoma stem-like cells (GSCs), together with their innate tumor-initiating aptitude, make this cell population a crucial target for effective therapies. However, targeting GSCs is hardly difficult and complex, due to the presence of the blood-brain barrier (BBB) and the infiltrative nature of GSCs arousing their dispersion within the brain parenchyma.

Methods

Liposomes (LIPs), surface-decorated with an Apolipoprotein E-modified peptide (mApoE) to enable BBB crossing, were loaded with doxorubicin (DOXO), as paradigm of cytotoxic drug triggering immunogenic cell death (ICD). Patient-derived xenografts (PDXs) obtained by GSC intracranial injection were treated with mApoE-DOXO-LIPs alone or concomitantly with radiation.

Resu

SUBMITTER: Pizzocri M 

PROVIDER: S-EPMC8349181 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature