Nutrition, one-carbon metabolism and arsenic methylation.

ABSTRACT: Exposure to arsenic (As) is a major public health concern globally. Inorganic As (InAs) undergoes hepatic methylation to form monomethyl (MMAs)- and dimethyl (DMAs)-arsenical species, facilitating urinary As elimination. MMAs^III is considerably more toxic than either InAs^III or DMAs^V, and a higher proportion of MMAs in urine has been associated with risk for a wide range of adverse health outcomes. Efficiency of As methylation differs substantially between species, between individuals, and across populations. One-carbon metabolism (OCM) is a biochemical pathway that provides methyl groups for the methylation of As, and is influenced by folate and other micronutrients, such as vitamin B₁₂, choline, betaine and creatine. A growing body of evidence

SUBMITTER: Abuawad A 

PROVIDER: S-EPMC8349595 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature