Fe₃O₄ magnetic nanoparticle-enhanced radiotherapy for lung adenocarcinoma via delivery of siBIRC5 and AS-ODN.

ABSTRACT:

Background

Radiotherapy is the mainstay treatment for lung adenocarcinoma, yet remains highly susceptible to resistance. Fe₃O₄ magnetic nanoparticles (MNPs) possess the ability to induce biological therapeutic effects. Herein, the current study set out to explore the effects of Fe₃O₄ MNPs on radiosensitivity of lung adenocarcinoma cells.

Methods

Fe₃O₄ MNPs loaded with both negatively-charged small interfering RNA against baculoviral IAP repeat containing 5 (siBIRC5) and oligodeoxynucleotide antisense (AS-ODN) to generate co-delivery NPs, followed by evaluation. Gel retardation assay was further performed to determine the binding ability of Fe₃O₄ MNPs to AS-ODN/siBIRC5. The radiosensitizin

SUBMITTER: Chen S 

PROVIDER: S-EPMC8351328 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature