Expansion of CD45RA^-FOXP3⁺⁺ regulatory T cells is associated with immune tolerance in patients with combined kidney and bone marrow transplantation.

ABSTRACT:

Objectives

Simultaneous transplantation of a solid organ and bone marrow from the same donor is a possible means of achieving transplant tolerance. Here, we attempted to identify biomarkers that indicate transplant tolerance for discontinuation of immunosuppressants in combined kidney and bone marrow transplantation (CKBMT).

Methods

Conventional kidney transplant (KT) recipients (n = 20) and CKBMT recipients (n = 6) were included in this study. We examined various immunological parameters by flow cytometry using peripheral blood mononuclear cells (PBMCs), including the frequency and phenotype of regulatory T (Treg) cell subpopulations. We also examined the suppressive activity of the Treg cell population in the setting of mixed lymphocyte reaction (MLR) with or

SUBMITTER: Kwon Y 

PROVIDER: S-EPMC8353318 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature