Ovulatory upregulation of angiotensin-converting enzyme 2, a receptor for SARS-CoV-2, in dominant follicles of the human ovary.

ABSTRACT:

Objective

To determine the temporal expression of angiotensin-converting enzyme 2 (ACE2), a receptor for SARS-CoV-2, in dominant follicles throughout the periovulatory period in women and the regulatory mechanisms underlying ACE2 expression in human granulosa/lutein cells (hGLC).

Design

Experimental prospective clinical study and laboratory-based investigation.

Setting

University Medical Center and private in vitro fertilization center.

Patient(s)

Thirty premenopausal women undergoing surgery for tubal ligation and 16 premenopausal women undergoing in vitro fertilization.

Intervention(s)

Administration of human chorionic gonadotropin (hCG) and harvesting of preovulatory/ovulatory follicles by timed laparoscopy, and collection of granulosa/lutein cells an

SUBMITTER: Choi Y 

PROVIDER: S-EPMC8354803 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature