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Fe-catalyzed Fukuyama-type indole synthesis triggered by hydrogen atom transfer.

ABSTRACT: Fe, Co, and Mn hydride-initiated radical olefin additions have enjoyed great success in modern synthesis, yet the extension of other hydrogen radicalophiles instead of olefins remains largely elusive. Herein, we report an efficient Fe-catalyzed intramolecular isonitrile-olefin coupling reaction delivering 3-substituted indoles, in which isonitrile was firstly applied as the hydrogen atom acceptor in the radical generation step by MHAT. The protocol features low catalyst loading, mild reaction conditions, and excellent functional group tolerance.

SUBMITTER: Zhang T

PROVIDER: S-EPMC8356753 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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Fe-catalyzed Fukuyama-type indole synthesis triggered by hydrogen atom transfer.

Zhang Tianze T Yu Min M Huang Hanmin H

Chemical science 20210706 31

Fe, Co, and Mn hydride-initiated radical olefin additions have enjoyed great success in modern synthesis, yet the extension of other hydrogen radicalophiles instead of olefins remains largely elusive. Herein, we report an efficient Fe-catalyzed intramolecular isonitrile-olefin coupling reaction delivering 3-substituted indoles, in which isonitrile was firstly applied as the hydrogen atom acceptor in the radical generation step by MHAT. The protocol features low catalyst loading, mild reaction co ...[more]

PMID: 34447542

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