Effects of Vitamin D and Dexamethasone on Lymphocyte Proportions and Their Associations With Serum Concentrations of 25-Hydroxyvitamin D₃ In Vitro in Patients With Multiple Sclerosis or Neuromyelitis Optica Spectrum Disorder.

ABSTRACT:

Background

Clear associations have been found between vitamin D deficiency and several autoimmune diseases including multiple sclerosis (MS). However, the benefits of vitamin D supplementation on disease management remain a matter of debate.

Objective and methods

Patients with MS (N=12) and neuromyelitis optica spectrum disorder (NMOSD; N=12) were enrolled along with 15 healthy controls. Changes in lymphocyte subset proportions during stimulation of their peripheral blood mononuclear cells (PBMCs) with the active form of vitamin D, 1,25-dihydroxyvitamin D₃ (1,25(OH)₂D₃), and correlations with serum concentrations of the vitamin D precursor 25-hydroxyvitamin D₃ (serum 25(OH)D₃) were explored. The impact of 1

SUBMITTER: Cho EB 

PROVIDER: S-EPMC8358328 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature