Saccade, Pupil, and Blink Responses in Rapid Eye Movement Sleep Behavior Disorder.

ABSTRACT:

Background

Parkinson's disease (PD) patients exhibit deficits in saccade performance, pupil function, and blink rate. Isolated REM (rapid eye movement) Sleep Behavior Disorder (RBD) is a harbinger to PD making them candidates to investigate for early oculomotor abnormalities as PD biomarkers.

Objectives

We tested whether saccade, pupillary, and blink responses in RBD were similar to PD.

Methods

RBD (n = 22), PD (n = 22) patients, and healthy controls (CTRL) (n = 74) were studied with video-based eye-tracking.

Results

RBD patients did not have significantly different saccadic behavior compared to CTRL, but PD patients differed from CTRL and RBD. Both patient groups had significantly lower blink rates, dampened pupil constriction, and dilation responses compared

SUBMITTER: Perkins JE 

PROVIDER: S-EPMC8359943 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature