Reversible Photothermal Modulation of Electrical Activity of Excitable Cells using Polydopamine Nanoparticles.

ABSTRACT: Advances in the design and synthesis of nanomaterials with desired biophysicochemical properties can be harnessed to develop non-invasive neuromodulation technologies. Here, the reversible modulation of the electrical activity of neurons and cardiomyocytes is demonstrated using polydopamine (PDA) nanoparticles as photothermal nanotransducers. In addition to their broad light absorption and excellent photothermal activity, PDA nanoparticles are highly biocompatible and biodegradable, making them excellent candidates for both in vitro and in vivo applications. The modulation of the activity (i.e., spike rate of the neurons and beating rate of cardiomyocytes) of excitable cells can be finely controlled by varying the excitation power density and irradiation duration. Under optimal conditions,

SUBMITTER: Gholami Derami H 

PROVIDER: S-EPMC8363531 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature