Ontology highlight
ABSTRACT:
SUBMITTER: Valiulahi P
PROVIDER: S-EPMC8365029 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Valiulahi Parvin P Vidyawan Vincencius V Puspita Lesly L Oh Youjin Y Juwono Virginia Blessy VB Sittipo Panida P Friedlander Gilgi G Yahalomi Dayana D Sohn Jong-Woo JW Lee Yun Kyung YK Yoon Jeong Kyo JK Shim Jae-Won JW
Stem cell reports 20210708 8
Serotonin (5-HT) neurons, the major components of the raphe nuclei, arise from ventral hindbrain progenitors. Based on anatomical location and axonal projection, 5-HT neurons are coarsely divided into rostral and caudal groups. Here, we propose a novel strategy to generate hindbrain 5-HT neurons from human pluripotent stem cells (hPSCs), which involves the formation of ventral-type neural progenitor cells and stimulation of the hindbrain 5-HT neural development. A caudalizing agent, retinoid aci ...[more]