Dataset Information

Case Report: Mitral Valve Involvement and First-Degree Atrial-Ventricular Block in Two Patients With Multisystem Inflammatory Syndrome in Children.

ABSTRACT: COVID-19 seems to be less frequent and severe in children compared to adults. Despite the very few symptoms usually found in children, great attention was recorded when in April 2020 a hyperinflammatory process in children with fever and multiorgan involvement after a paucisymptomatic COVID infection was reported. The United States Centers for Disease Control and the World Health Organization recognized and defined this syndrome as "Multisystem Inflammatory Syndrome in Children (MIS-C)." We describe two cases of MIS-C presenting with fever, cutaneous rash, and a mild cardiac involvement expressed with a transient mitral valve involvement and a first-degree atrioventricular block. Acute treatment was managed with intravenous immunoglobulin, oral aspirin, and intravenous corticosteroids reaching consequent good outcome. Clinical characteristics, treatment management, follow-up, and long-term evolution of children with MIS-C are still poorly defined. Further research is needed to better understand the pathogenesis of this newly described condition, to validate a high-level recommended therapy and a specific therapy tapering timings.

SUBMITTER: Di Filippo P

PROVIDER: S-EPMC8377535 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Case Report: Mitral Valve Involvement and First-Degree Atrial-Ventricular Block in Two Patients With Multisystem Inflammatory Syndrome in Children.

Di Filippo Paola P Raso Massimiliano M Cacciatore Marta M Patacchiola Roberta R Renda Giulia G Rossi Nadia N Chiarelli Francesco F

Frontiers in pediatrics 20210806

COVID-19 seems to be less frequent and severe in children compared to adults. Despite the very few symptoms usually found in children, great attention was recorded when in April 2020 a hyperinflammatory process in children with fever and multiorgan involvement after a paucisymptomatic COVID infection was reported. The United States Centers for Disease Control and the World Health Organization recognized and defined this syndrome as "Multisystem Inflammatory Syndrome in Children (MIS-C)." We desc ...[more]

PMID: 34422717

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Project description:ObjectivesThis study aimed to classify anatomical variations in aortic root rotation using preoperative three-dimensional transoesophageal echocardiography (3D-TEE), validate these findings with cardiac computed tomography (CT) in patients undergoing mitral valve surgery and evaluate the clinical impact on postoperative atrioventricular conduction disorders.MethodsA total of 126 patients with normal electrocardiograms who underwent isolated mitral valve surgery were included. Anatomical variation was diagnosed using 3D-TEE, and aortic root rotation angle was measured using cardiac CT. New-onset postoperative atrioventricular block (AVB) and bundle branch block were analysed.ResultsVariations of aortic root rotation were classified by 3D-TEE into two categories: 'center rotation' (normal) (85.7%, n = 108/126), where the commissure of the left and non-coronary aortic leaflet was located at center of the anterior mitral leaflet, and 'lateral rotation' (14.3%, n = 18/126), rotated to the lateral trigone side. The aortic root rotation angle, where the interatrial septum was defined as a reference, measured by cardiac CT strongly correlated with 3D-TEE findings ('center rotation' vs 'lateral rotation': 51.6° vs 64.6°, P < 0.001). The incidence of new-onset conduction disorder, all presenting with first-degree AVB, was significantly higher in the 'lateral rotation' than in the 'center rotation' (38.9% [n = 7/18] vs 5.6% [n = 6/108], P < 0.001). Aortic root rotation angles were identified as significant risk factors for postoperative first-degree AVB (odds ratio, 1.05; 95% confidential interval, 1.01-1.09; P = 0.027), with cutoff values of 58.7° predicting persistent new-onset AVB.ConclusionsAortic root rotation angle measured by cardiac CT validated 3D-TEE diagnosis of 'lateral rotation' of the aortic root. 'Lateral rotation' and larger aortic root rotation angles were significant risk factors for postoperative first-degree AVB following mitral valve surgery.

Dataset Information

Case Report: Mitral Valve Involvement and First-Degree Atrial-Ventricular Block in Two Patients With Multisystem Inflammatory Syndrome in Children.

Publications

Case Report: Mitral Valve Involvement and First-Degree Atrial-Ventricular Block in Two Patients With Multisystem Inflammatory Syndrome in Children.

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