Granzyme B prevents aberrant IL-17 production and intestinal pathogenicity in CD4⁺ T cells.

ABSTRACT: CD4⁺ T cell activation and differentiation are important events that set the stage for proper immune responses. Many factors are involved in the activation and differentiation of T cells, and these events are tightly controlled to prevent unwanted and/or exacerbated immune responses that may harm the host. It has been well-documented that granzyme B, a potent serine protease involved in cell-mediated cytotoxicity, is readily expressed by certain CD4⁺ T cells, such as regulatory T cells and CD4⁺CD8αα⁺ intestinal intraepithelial lymphocytes, both of which display cytotoxicity associated with granzyme B. However, because not all CD4⁺ T cells expressing granzyme B are cytotoxic, additional roles for this protease in CD4⁺ T cell

SUBMITTER: Hoek KL 

PROVIDER: S-EPMC8380717 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature