Neonatal Maternal Separation Modifies Proteostasis Marker Expression in the Adult Hippocampus.

ABSTRACT: Exposure to early-life stress (ELS) can persistently modify neuronal circuits and functions, and contribute to the expression of misfolded and aggregated proteins that are hallmarks of several neurodegenerative diseases. The healthy brain is able to clear dysfunctional proteins through the ubiquitin-proteasome system (UPS) and the autophagy-lysosomal pathway (ALP). Accumulating evidence indicates that impairment of these pathways contributes to enhanced protein aggregation and neurodegeneration. While stress is a known precipitant of neurological decline, few specific mechanistic links underlying this relationship have been identified. We hypothesized that neonatal maternal separation (MatSep), a well-established model of ELS, has the ability to alter the levels of UPS and ALP components i

SUBMITTER: Sierra-Fonseca JA 

PROVIDER: S-EPMC8383781 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature