The low contagiousness and new A958D mutation of SARS-CoV-2 in children: An observational cohort study.

ABSTRACT:

Aims

To explore the contagiousness and new SARS-CoV-2 mutations in pediatric COVID-19.

Methods

This cohort study enrolled all pediatric patients admitted to 8 hospitals in Zhejiang Province of China between 21 January and 29 February 2020, their family members and close-contact classmates. Epidemiological, demographic, clinical and laboratory data were collected. Bioinformatics was used to analyze the features of SARS-CoV-2. Individuals were divided into 3 groups by the first-generation case: Groups 1 (unclear), 2 (adult), and 3 (child). The secondary attack rate (SAR) and R₀ were compared among the groups.

Results

The infection rate among 211 individuals was 64% (135/211). The SAR in Groups 2 and 3 was 71% (73/103) and 3% (1/30), respectively; the median R

SUBMITTER: Chen Y 

PROVIDER: S-EPMC8384730 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature