BloodGen3Module: blood transcriptional module repertoire analysis and visualization using R.

ABSTRACT:

Motivation

We previously described the construction and characterization of fixed reusable blood transcriptional module repertoires. More recently we released a third iteration ('BloodGen3' module repertoire) that comprises 382 functionally annotated modules and encompasses 14 168 transcripts. Custom bioinformatic tools are needed to support downstream analysis, visualization and interpretation relying on such fixed module repertoires.

Results

We have developed and describe here an R package, BloodGen3Module. The functions of our package permit group comparison analyses to be performed at the module-level, and to display the results as annotated fingerprint grid plots. A parallel workflow for computing module repertoire changes for individual samples rather than groups of sa

SUBMITTER: Rinchai D 

PROVIDER: S-EPMC8388021 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature