The Human Antibody Response to the Influenza Virus Neuraminidase Following Infection or Vaccination.

ABSTRACT: The influenza virus neuraminidase (NA) is primarily involved in the release of progeny viruses from infected cells-a critical role for virus replication. Compared to the immuno-dominant hemagglutinin, there are fewer NA subtypes, and NA experiences a slower rate of antigenic drift and reduced immune selection pressure. Furthermore, NA inhibiting antibodies prevent viral egress, thus preventing viral spread. Anti-NA immunity can lessen disease severity, reduce viral shedding, and decrease viral lung titers in humans and various animal models. As a result, there has been a concerted effort to investigate the possibilities of incorporating immunogenic forms of NA as a vaccine antigen in future vaccine formulations. In this review, we discuss NA-based immunity and describe several human NA-spe

SUBMITTER: Rajendran M 

PROVIDER: S-EPMC8402431 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature